Protective effects of a PPAR-δ agonist and a non-erythropoietic peptide derivative of erythropoietin against the diet-induced development of skeletal muscle insulin resistance and inflammation in mice
نویسندگان
چکیده
Dept. of Drug Science and Technology, University of Turin, Turin, Italy Dept. of Clinical and Biological Sciences, University of Turin, Turin, Italy Dept. of Biotechnology and Sciences for the Health, University of Turin, Italy ININCA-CONICET, Buenos Aires, Argentina Dept. of Molecular Medicine University of Pavia, Italy Division of Endocrinology, Diabetology and Metabolism, Dept. of Medical Sciences, University of Turin, Italy Queen Mary University of London, Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK
منابع مشابه
High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR-δ Agonism
Peroxisome Proliferator Activated Receptor (PPAR)- δ agonists may serve for treating metabolic diseases. However, the effects of PPAR- δ agonism within the skeletal muscle, which plays a key role in whole-body glucose metabolism, remain unclear. This study aimed to investigate the signaling pathways activated in the gastrocnemius muscle by chronic administration of the selective PPAR- δ agonist...
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تاریخ انتشار 2015